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| __NOTOC__
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| {{Bubble
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| | title=<span style="width:100%; height:100%; display:block;" class="mw-customtoggle-about">About Us[[File:People-icon.svg|x30px|right|link=]]</span>
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| | content=<div class="mw-collapsible" id="mw-customcollapsible-about">
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| <p class="panel-body">'''This wiki contains everything a budding mad (''gender'') scientist needs to further their work! Specifically, the driving goals behind this wiki are to:'''</p>
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| <ul class="content-table">
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| <li class="list-item"> '''Educate ourselves''' about the biology underlying transition and developmental sex differentiation. </li>
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| <li class="list-item"> '''Postulate and collect''' a compendium of hypothetical treatments that warrant further research. </li>
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| <li class="list-item"> '''Reduce harm''' by bringing together official standards of care for gender identities and intersex conditions.</li>
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| <li class="list-item"> '''Enable access''' to needed information freely to those who require help navigating the systems. </li>
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| <li class="list-item"> '''Provide a forum''' for people whom these conditions affect the most to become more educated and involved in the processes of their treatments, advancing healthcare ourselves! </li>
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| </ul>
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| </div>
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| <p class="panel-footer">Overview of our driving goals purpose.</p>
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| | title=<span style="width:100%; height:100%; display:block;" class="mw-customtoggle-contact">Contact Us[[File:Envelope.svg|x25px|right|link=]]</span>
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| | content=<div class="mw-collapsible" id="mw-customcollapsible-contact">
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| <ul class="content-table">
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| <li class="list-item">Come discuss your wild ideas with other mad scientists over on our IRC channels! See the [https://madgenderscience.wiki/wiki/Project_community_guidelines '''Project community guidelines'''] page for more information.</li>
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| <li class="list-item">'''[[User:CyborGhost | CyborGhost]]''', the co-founder and currently active content curator, can usually be reached on our IRC server. Or you can just leave a message on their [[User_talk:CyborGhost | talk page]].</li><li class="list-item">'''[[User:LilianaUmbra | LilianaUmbra]]''', the research librarian, is often on our IRC server. Or you can post a message on her [[User_talk:LilianaUmbra | talk page]].</li>
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| <li class="list-item">'''[[User:Mabel | Mabel]]''', the founder, can be sometimes be found on our IRC server. Or alternatively by leaving a message on her [[User_talk:Mabel | talk page]].</li>
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| </ul>
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| </div>
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| <p class="panel-footer">Come meet the team on our [https://madgenderscience.wiki/wiki/Project_community_guidelines IRC server!] .</p>
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| }}
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| {{Special:AllPages}}
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| </div>
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| <p class="panel-footer">A list of all [[Special:Statistics|{{NUMBEROFARTICLES}}]] articles that are available.</p>
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| | title=<span style="width:100%; height:100%; display:block;" class="mw-customtoggle-recent">Recent Changes[[File:Newspaper-icon.svg|x30px|right|link=]]</span>
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| {{Special:RecentChanges/100,minor=true}}
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| </div>
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| <p class="panel-footer">The most recent of all [[special:statistics|{{NUMBEROFEDITS}}]] changes.</p>
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| | title=<span style=" width:100%; height:100%; display:block;" class="mw-customtoggle-welcome">Research Updates[[File:Logo_simple2.svg|x30px|right|link=]]</span>
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| | content=<div class="mw-collapsible" id="mw-customcollapsible-welcome">
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| <div style="border:1px solid black; padding: 5px; border-color: #DDDDDD; margin-top: 15px; margin-bottom: 15px; margin-right: 15px; margin-left: 15px;">
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| <blockquote><span style="font-size:medium">'''[[Featured research]]'''</span>
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| <choose> | | <choose> |
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/28914501 Andrology of male-to-female transsexuals: influence of cross-sex hormone therapy on testicular function.]'''</h5> | | <option><div style="margin-right:2%;">[[File:Il 570xN.4242932031 q1n9.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| A review of previous studies which looks into the efficacy of standard feminizing HRT for the treatment of gender dysphoria. The review aims to analyze the past techniques and their goals, then proposing improvements that can help increase the reliability of achieving the intended effects of HRT.</option>
| | <option><div style="margin-right:2%;">[[File:Il 570xN.4242915525 dj8o.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| | | <option><div style="margin-right:2%;">[[File:Il 570xN.4242889125 s3w2.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/27833161 12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study.]'''</h5> | | <option><div style="margin-right:2%;">[[File:Il 570xN.4242857333 4z7v.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| An in depth study which looks into how HRT changes the metabolism of trans men and women. Since many metabolic processes are sexually dimorphic this study can help determine to what extent pre-transition development vs subsequent HRT may effect the metabolism of trans people in contrast to cis people.</option>
| | <option><div style="margin-right:2%;">[[File:Il 570xN.4242842653 2ku7.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| | | <option><div style="margin-right:2%;">[[File:Il 570xN.4242781327 dt0z.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/29144822 Testosterone levels achieved by medically treated transgender women in a United States endocrinology clinic.]'''</h5> | | <option><div style="margin-right:2%;">[[File:Il 570xN.4195276310 j86m.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| This study assessed the anonymous medical records of 98 trans women taking spironolactone as part of their feminizing regimen, and assessed how much their testosterone levels dropped over time. ''* Please note that spironolactone is not an anti-gonadotropin and thus does not aim to suppress testosterone production, instead it is an androgen receptor antagonist and instead prevents androgens from activating the receptor. This is a common misconception that can lead to fairly useless data when testing for testosterone levels.''</option>
| | <option><div style="margin-right:2%;">[[File:Il 570xN.4195267542 obn5.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| | | <option><div style="margin-right:2%;">[[File:Il 570xN.4195263170 1bxy.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/30025172 Testosterone undecanoate and testosterone enanthate injections are both effective and safe in transmen over 5 years of administration.]'''</h5>
| | <option><div style="margin-right:2%;">[[File:Il 570xN.4195248244 8dur.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
| A study evaluating the safety and efficacy of testosterone undecanoate and enanthate injections in 50 trans men for over 5 years. The study has concluded that such injections are safe and effective within the studies scope, shown through parameters of physical health and satisfaction.</option>
| | <option><div style="margin-right:2%;">[[File:Il 570xN.4195214980 bkfa.png|thumb|right|200px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194|'''Products available on Etsy''']]</div></option> |
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/31229517 A Retrospective Cohort Study on Surgical Outcomes of Penile Prosthesis Implantation Surgery in Transgender Men After Phalloplasty.]'''</h5> | |
| This study attempted to assess the surgical outcomes of penile prosthetic implants by looking at the frequency of complications and reoperations occurring in various types of phalloplasty. The researchers recommend that patients should be better informed about these complications and their rates.</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/31127826 Medroxyprogesterone Acetate in Gender-Affirming Therapy for Transwomen: Results From a Retrospective Study.]'''</h5> | |
| This is the first study aiming to investigate the side effects of medroxyprogesterone in the transgender population. The side effects which were self-reported by the population included improved breast development, decreased facial hair, and mood swings. The testing of hormone levels indicated no change in estrogen, yet a decrease in testosterone.</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612061/ Cyproterone acetate or spironolactone in lowering testosterone concentrations for transgender individuals receiving oestradiol therapy.]'''</h5> | |
| A comparison between the ability of cyproterone acetate and spironolactone to lower testosterone levels. Although it shows that cyproterone has a greater effect towards lowering testosterone levels, it ironically notes '''this metric isn't very meaningful''' since spironolactone is only an antagonist and does not inhibit steroidogenesis.</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/30602475 Venous Thrombotic Risk in Transgender Women Undergoing Estrogen Therapy: A Systematic Review and Metaanalysis.]'''</h5>
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| A study which concluded the risk for venothrombotic disease due to estrogen therapy may be overstated and further study is required to have reason limit it's prescription based on the commonly feared factors (age, tobacco use, obesity) specifically with more data on risk factors in relation to routes of administration.</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/31098694 Safety of Combined Facial Plastic Procedures Affecting Multiple Planes in a Single Setting in Facial Feminization for Transgender Patients.]'''</h5> | |
| A retrospective analysis on the safety of doing multiple facial feminization procedures at once. The study concluded that although there were complications experienced, they were within the expected range of potential issues for such complex surgeries, and despite the issues all came through with "good cosmetic results".</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051275/ Feminizing the Face: Combination of Frontal Bone Reduction and Reduction Rhinoplasty.]'''</h5>
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| A series of case studies which looked into the safety and efficacy of performing both brow and nose facial feminization surgery at the same time, noting that this combination is not only safe, but beneficial as it allows for better coordination and less hospital time/costs.</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711503/ Comparing the health of non-binary and binary transgender adults in a statewide non-probability sample.]'''</h5> | |
| A comparison between the health of non-binary vs. binary transgender patients, which showed that there was significant statistical differances between them in terms of health and social factors, with non-binary individuals seemingly being more at-risk in many areas (though not all), mainly in those seen commonly in minority stress.</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603217/ Health of Non-binary and Genderqueer People: A Systematic Review.]'''</h5> | |
| A review analyzing prior looks at the health needs of non-binary/genderqueer patients, showing that there is a lack of look into attempts to improve their mental health. It only noted one instance of such a paper, which was focused on the chest surgery outcomes of transmasculine patients. Thus the review concludes there is a shortage of research on this subject which should be expanded.</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pubmed/31451850 Masculinizing Chest Reconstruction in Transgender and Nonbinary Individuals: An Analysis of Epidemiology, Surgical Technique, and Postoperative Outcomes.]'''</h5>
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| A look at the safety of both mastectomy and breast reduction in both binary and non-binary transmasculine patients. They conclude that both mastectomy and reduction, with or without nipple graft are all safe within the transmasculine population, and that these results may be useful as a way to discuss between patients and providers which option may lead to the ideal outcome.</option>
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| <option><h5>'''[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651354/ LGBT+ Health Teaching within the Undergraduate Medical Curriculum.]'''</h5> | |
| A pilot study into the effectiveness of including a mandatory LGBT+ program into an undergraduate medical curriculum. The change in the students confidence at properly interacting with and assessing the LGBT population was shown to dramatically increase based on self reported statistics.</option>
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| <blockquote>
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| The '''[[Papers]]''' page is a thorough compendium of up-to-date trans-specific research with a high quality of evidence, as well as guides on ways to access them, or find more research.
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| <br><br>
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| It is at the heart of all our goals stated in the '''"About Us"''' tab below, and one of the more polished articles on the wiki having been curated by our research librarian '''LilianaUmbra'''.
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| </blockquote> | |
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| <p class="panel-footer">There are [[special:statistics | {{NUMBEROFACTIVEUSERS}}]] users currently working on this wiki.</p>
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| <blockquote><span style="font-size:medium">'''[https://madgenderscience.wiki/wiki/Category:Featured Featured article]'''</span>
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| <option>{{#lst:Endocrine Society Guidelines|Endocrine Society Guidelines}}</option>
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| <p class="panel-footer">There are [[Special:statistics | {{PAGESINCATEGORY:featured}}]] [[:category:featured | featured articles]] made so far.</p>
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| </div> | | , <s>'''[https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298623982 or purchasing merch]'''</s> [[File:Etsy.jpg|x25px|link=https://www.etsy.com/ca/shop/Umbrary?ref=simple-shop-header-name&listing_id=1298612194]]. |
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